groovy dependencies { implementation 'androidx.multidex:multidex:2.0.1' } public class MyApplication extends MultiDexApplication { // ... } @Override public void onCreate() { super.onCreate(); MultiDex.install(this); // ... } # Keep the support library classes -keep class android.support.multidex.** { *; } # Keep the classes required by Multi Dex Library -keep public class androidx.multidex.MultiDexInstaller { public *; } -keep public class androidx.multidex.MultiDexExtractor { public *; } # Additional configuration when using ProGuard with Instant Run -dontoptimize -keepattributes *Annotation*,EnclosingMethod,Signature -keepattributes InnerClasses,EnclosingMethod -keepattributes Signature -keepattributes Exceptions # Disable resource shrinking -keepresources string/* !androidx/multidex/**/* # You may need to keep other classes and methods based on your app's specific requirements